Mitochondrially targeted antioxidants
AssigneesMedical Research Council, University of Otago
InventorsMichael P. Murphy, Robin A. J. Smith
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Abstract
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
Claims11
A compound comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is a superoxide dismutase (SOD) mimetic wherein the lipophilic cation moiety is a tribenzyl or triphenyl substituted ammonium or phosphonium moiety.
Dependencies are inferred from the claim text.