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US 6,984,386 B2Granted
Nanoscale particles synthesized within an assembled virion
AssigneeThe Research and Development Institute, Inc.
InventorsTrevor Douglas, Mark J. Young
Life of this patent
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Abstract
Virion-constrained nanoparticles comprising a shell of virion coat protein(s) surrounding an organic, inorganic and/or organo-metallic non-viral nanoparticle and methods of making and using.
Claims17
A virion-constrained nanoparticle comprising a non-plant virion coat protein shell surrounding a nanoparticle of non-viral origin selected from the group consisting of organic, inorganic and organo-metallic materials.
A process for producing virion-constrained nanoparticles comprising a non-plant virion coat protein shell surrounding a nanoparticle of non-viral origin comprising the following steps:
- a) providing isolated and substantially purified animal virion coat protein shells containing controllable gates;
- b) incubating the virion coat protein shell in a solution comprising one or more organic, inorganic, and/or organometallic materials under conditions that permit controlled entry of the materials into the virion shell;
- c) adjusting the solution conditions in such a manner that the virion coat protein shell entrap s the materials of step b);
- and
- d) isolating the virion-constrained nanoparticles produced.
2 more elements
Dependencies are inferred from the claim text.