Aminoethanol derivatives
AssigneeTakeda Pharmaceutical Company Limited
InventorsMasakuni Kori, Kazumasa Hamamura, Hiromitsu Fuse, Toshihiro Yamamoto
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Abstract
The present invention provides a pharmaceutical agent having cholesteryl ester transfer protein inhibitory action and useful as a blood lipid lowering agent and the like. The present invention relates to a compound represented by the formula wherein Ar1 is an aromatic ring group optionally having substituents, Ar2 is an aromatic ring group having substituents, OR″ is an optionally protected hydroxyl group, R is an acyl group, R′ is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof, and a pharmaceutical composition containing a compound of the formula (I) or a salt thereof or a prodrug thereof.
Claims55
A compound represented by the formula
- wherein
- Ar1 is an aromatic ring group optionally having substituents,
- Ar2 is an aromatic ring group having substituents,
- OR″ is an optionally protected hydroxyl group,
- R is an acyl group, and
- R' is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof;
- except tert-butyl benzyl-[2(S)-hydroxy-2-thiazol-2-yl-1(S)-(4-trifluoromethyl-benzyl)-ethyl]-carbamate.
A prodrug of a compound represented by the formula
- wherein
- Ar1 is an aromatic ring group optionally having substituents
- Ar2 is an aromatic ring group having substituents,
- OR″ is an optionally protected hydroxyl group,
- R is an acyl group, and R′ is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof,
- except tert-butyl benzyl-[2(S)-hydroxy-2-thiazol-2-yl-1(S)-(4-trifluoromethyl-benzyl)-ethyl]-carbamate.
A pharmaceutical composition comprising a compound represented by the formula
- wherein
- Ar1 is an aromatic ring group optionally having substituents,
- Ar2 is an aromatic ring group having substituents,
- OR″ is an optionally protected hydroxyl group,
- R is an acyl group, and
- R′ is a hydrogen atom or a hydrocarbon group optionally having substituents,
- or a salt thereof of a prodrug thereof.
A cholesteryl ester transfer protein inhibitor comprising a compound represented by the formula
- wherein
- Ar1 is an aromatic ring group optionally having substituents,
- Ar2 is an aromatic ring group optionally having substituents,
- OR″ is an optionally protected hydroxyl group,
- R is an acyl group, and
- R′ is a hydrogen atom or a hydrocarbon group optionally having substituents,
- or a salt thereof or a prodrug thereof.
Dependencies are inferred from the claim text.