Modified carbocyanine dyes and their conjugates
AssigneeMolecular Probes, Inc.
InventorsWai-Yee Leung, Ching-Ying Cheung, Stephen Yue
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
Claims5
A compound having the formula:
- and its salts, wherein
- R2 is alkyl or sulfoalkyl;
- R12 is alkyl or sulfoalkyl;
- R3 is carboxyalkyl;
- R4 is alkyl;
- R13 is alkyl;
- R14 is alkyl;
- R6 is hydrogen or sulfo;
- R7 is hydrogen or sulfo;
- R8 is hydrogen or sulfo;
- R9 is hydrogen or sulfo;
- R16 is hydrogen or sulfo;
- R17 is hydrogen or sulfo;
- R18 is hydrogen or sulfo;
- R19 is hydrogen or sulfo;
- wherein sulfo is sulfonic acid or sulfonate;
- and,
- n is 1, 2 or 3.
A compound having the formula:
- and its salts, wherein,
- R2 is alkyl or sulfoalkyl;
- R12 is alkyl or sulfoalkyl;
- wherein sulfo is sulfonic acid or sulfonate;
- R3 is carboxyalkyl;
- R4 is methyl;
- R13 is methyl;
- R14 is methyl;
- and,
- n is 1, 2 or 3.
A compound having the formula:
- and its salts, wherein
- R2 is alkyl or sulfoalkyl;
- R12 is alkyl or sulfoalkyl;
- R4 is alkyl;
- R13 is alkyl;
- R14 is alkyl;
- R6 is hydrogen or sulfo;
- R7 is hydrogen or sulfo;
- R8 is hydrogen or sulfo;
- R9 is hydrogen or sulfo;
- R16 is hydrogen or sulfo;
- R17 is hydrogen or sulfo;
- R18 is hydrogen or sulfo;
- R19 is hydrogen or sulfo;
- wherein sulfo is sulfonic acid or sulfonate;
- and,
- n is 1, 2 or 3.
A compound having the formula:
- and its salts, wherein
- R2 is alkyl or sulfoalkyl;
- R12 is alkyl or sulfoalkyl;
- R4 is alkyl;
- R13 is alkyl;
- R14 is alkyl;
- R6 is hydrogen or sulfo;
- R7 is hydrogen or sulfo;
- R8 is hydrogen or sulfo;
- R9 is hydrogen or sulfo;
- R16 is hydrogen or sulfo;
- R17 is hydrogen or sulfo;
- R18 is hydrogen or sulfo;
- R19 is hydrogen or sulfo;
- wherein sulfo is sulfonic acid or sulfonate;
- and,
- n is 1, 2 or 3.
A compound having the formula:
- and its salts, wherein
- R2 is alkyl or sulfoalkyl;
- R12 is alkyl or sulfoalkyl;
- wherein sulfo is sulfonic acid or sulfonate;
- and,
- n is 1, 2 or 3.
Dependencies are inferred from the claim text.