Oligodeoxynucleotide and its use to induce an immune response
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsDennis Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
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Abstract
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
Claims13
A substantially pure or isolated oligodeoxynucleotide of between 18 and 30 nucleotides in length, comprising any one of
- 5′-X1X2TGCATCGATGCAGGGGGG-3′;
- (SEQ ID NO:12)
- 5′-X1X2TGCACCGGTGCAGGGGGG-3′;
- (SEQ ID NO:13)
- 5′-X1X2TGCGTCGACGCAGGGGGG-3′;
- (SEQ ID NO:15)
- 5′-X1X2TGCGCCGGCGCAGGGGGG-3′;
- (SEQ ID NO:17)
- 5′-GGTGCATCGATGCAGGGGGG-3′;
- (SEQ ID NO:1)
- 5′-GGTGCGTCGACGCAGGGGGG-3′;
- (SEQ ID NO:31)
- 5′-GGTGCACCGGTGCAGGGGGG-3′;
- or
- (SEQ ID NO:2)
- 5′-GGTGCATCGATGCAGGGGG-3′;
- (SEQ ID NO:73).
Dependencies are inferred from the claim text.