Insoluble drug delivery
AssigneesJagotec AG, Board of Regents, The University of Texas System
InventorsInge B Henriksen, Awadesh K. Mishra, Gary W. Pace, Keith P. Johnston, Simon Mawson
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Abstract
Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
Claims17
A process of preparing microparticles up to 300 nm in size of water-insoluble or substantially water-insoluble biologically active compounds comprising the steps of:
- (1) dissolving a water-insoluble or substantially water-insoluble biologically active compound in a solvent therefor to form a solution;
- and
- (2) spraying the solution prepared in step (1) into a compressed gas, liquid or supercritical fluid in the presence of a surface modifier dispersed or dissolved in an aqueous phase.
A process of preparing microparticles up to 300 nm in size of a water-insoluble or substantially water-insoluble biologically active compound comprising the steps of:
- (1) dissolving a water-insoluble or substantially water-insoluble biologically active compound in a compressed fluid;
- (2) preparing an aqueous phase containing a surface modifier active at the compound-water interface;
- and
- (3) spraying the compressed fluid of step (1) into the aqueous phase of step (2) to form microparticles of the compound.
Dependencies are inferred from the claim text.