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US 6,967,086 B2Granted
Method for determining the presence or absence of respiring cells on a three-dimensional scaffold
AssigneeBecton, Dickinson and Company
InventorsRichard David Guarino, John Jacob Hemperly, Catherine A. Spargo, Andrea Liebmann-Vinson, Mohammad A. Heidaran
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Abstract
The invention provides a method and apparatus for determining the presence or absence of respiring cells, involving combining a three-dimensional biomimetic scaffold and cells onto a sensor composition.
Claims21
A method for determining presence or absence of respiring cells comprising:
- (i) depositing a three-dimensional biomimetic scaffold and cells onto a sensor composition, said sensor composition comprising a luminescent compound that exhibits a change in luminescent property when irradiated with light containing wavelengths which cause said compound to luminesce upon exposure to oxygen;
- (ii) irradiating said sensor composition with light to cause luminescence;
- (iii) determining the resultant luminescent light intensity emitted;
- (iv) determining, based on said emitted luminescent light intensity, the presence or absence of respiring cells.
1 more element
Dependencies are inferred from the claim text.