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US 6,962,815 B2Granted
AAV2 vectors and methods
AssigneeChildren's Hopital Inc.
InventorJeffrey S. Bartlett
Life of this patent
Estimating the term…
Abstract
The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.
Claims25
An AAV2 vector comprising a capsid protein with a peptide insertion at a position selected from the group consisting of:
- (a) position 139 in the VP1 capsid (SEQ ID NO:
- 13) and
- (b) position 161 in the VP1 capsid (SEQ ID NO:
- 13).
1 more element
An AAV2 vector comprising a capsid protein with a peptide insertion at a position selected from the group consisting of:
- (a) position 459 in the VP1 capsid (SEQ ID NO:
- 13);
- (b) position 584 in the VP1 capsid (SEQ ID NO:
- 13);
- (c) position 588 in the VP1 capsid (SEQ ID NO:
- 13);
- and
- (d) position 657 in the VP1 capsid (SEQ ID NO:
- 13).
6 more elements
A polynucleotide encoding an AAV2 capsid protein with a peptide insertion at a position selected from the group consisting of:
- position 139 in the VP1 capsid (SEQ ID NO:13), position 161 in the VP1 capsid (SEQ ID NO:13), position 459 in the VP1 capsid (SEQ ID NO:13), position 584 in the VP1 capsid (SEQ ID NO:13), position 588 in the VP1 capsid (SEQ ID NO:13) and position 657 in the VP1 capsid (SEQ ID NO:13).
Dependencies are inferred from the claim text.