Sample desorption/ionization from mesoporous silica
AssigneeThe Regents of the University of California
InventorsSrinivas Iyer, Andrew M. Dattelbaum
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Abstract
Mesoporous silica is shown to be a sample holder for laser desorption/ionization of mass spectrometry. Supported mesoporous silica was prepared by coating an ethanolic silicate solution having a removable surfactant onto a substrate to produce a self-assembled, ordered, nanocomposite silica thin film. The surfactant was chosen to provide a desired pore size between about 1 nanometer diameter and 50 nanometers diameter. Removal of the surfactant resulted in a mesoporous silica thin film on the substrate. Samples having a molecular weight below 1000, such as C60 and tryptophan, were adsorbed onto and into the mesoporous silica thin film sample holder and analyzed using laser desorption/ionization mass spectrometry.
Claims25
A method for performing laser desorption mass spectrometry comprising:
- forming an ordered nanocomposite thin film on a substrate, the thin film comprising a surfactant;
- removing the surfactant to transform the film into mesoporous silica thin film;
- adsorbing a sample on the mesoporous silica thin film;
- exposing the mesoporous silica thin film with adsorbed sample to a laser light beam in an ion-generating section of a mass spectrometer to desorb and ionize the sample;
- and
- detecting the desorbed and ionized sample.
A method for performing laser desorption mass spectrometry comprising:
- preparing a self-assembled, ordered, nanocomposite, silica thin film on a substrate;
- the self-assembled, ordered, nanocomposite silica thin film comprising a surfactant chosen to produce an ordered mesoporous silica thin film having a desired pore size;
- removing the surfactant to form the ordered mesoporous silica thin film;
- adsorbing a sample on the mesoporous silica thin film;
- exposing the mesoporous silica thin film to a laser light beam in an ion generating section of a mass spectrometer to desorb and ionize the sample;
- and
- detecting the desorbed and ionized sample.
A method for performing laser desorption mass spectrometry comprising:
- adsorbing a sample on mesoporous silica comprising a pore size of from about 1 nanometer to about 50 nanometers wherein the mesoporous silica is prepared by forming an ordered nanocomposite thin film on a substrate, the thin film comprising a surfactant;
- and removing the surfactant to transform the film into mesoporous silica thin film;
- exposing the mesoporous silica to a laser light beam in an ion-generating section of a mass spectrometer to desorb and ionize the sample;
- and
- detecting the desorbed and ionized sample.
Dependencies are inferred from the claim text.