Transgenic mice overexpressing aspartyl protease 2 (ASP2)
AssigneeSmithKline Beecham Corporation
InventorsMartin Geppert, Alexander James Harper, Steve Mark Harrison, Haydn Prosser
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Abstract
The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked to the coding sequence. The present invention further provides a transgenic non-human animal whose genome incorporates a polynucleotide comprising a coding sequence which encodes the human ASP2 protein wherein the coding sequence is operably linked to a brain-specific calcium calmodulin kinase II promoter.
Claims3
A recombinant DNA construct comprising a coding sequence encoding human aspartyl protease 2 (ASP2) and a brain-specific calcium calmodulin kinase II promoter sequence which is operably linked to the coding sequence.
A transgenic mouse whose genome incorporates a polynucleotide comprising a coding sequence which encodes the human ASP2 protein wherein said coding sequence is operably linked to a brain-specific calcium calmodulin kinase II promoter, and where said human Asp2 protein is expressed in the hippocampus of the mouse.
A transgenic mouse cell whose genome incorporates a nucleotide comprising a coding sequence which encodes the human ASP2 protein and a brain-specific calcium calmodulin kinase II promoter sequence which is operably linked to the coding sequence.
Dependencies are inferred from the claim text.