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US 6,958,411 B2Granted
Nordihydroguaiartic derivatives for use in treatment of tumors
AssigneeThe Johns Hopkins University
InventorsRu Chih C. Huang, Jonathan D. Heller, Jih Ru Hwu, Ko Yung King
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Abstract
Nordihydroguaiaretic acid derivatives and methods of use thereof for the treatment of tumors.
Claims16
A method of synthesizing a chloride salt of a compound of the formula
- wherein R1, R2, R3, and R4 are identical and represent an amino acid residue or N,N-dimethyl substituted amino acid residue comprising the steps of:
- (a) combining nordihydroguaiaretic acid (NDGA) and an amino acid or N,N-dimethyl substituted amino acid;
- and
- (b) adding hydrogen chloride;
- wherein these steps are performed under conditions to produce a chloride salt of a derivative of NDGA.
2 more elements
Dependencies are inferred from the claim text.