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US 6,958,398 B1Granted
Methods for making thebaine or its acid salts
AssigneeEuro-Celtique S.A.
InventorsRobert J. Kupper, Arie Gutman, Igor Rukhman, Lev Yudovich, Gennady A. Nisnevich
Life of this patent
Estimating the term…
Abstract
Methods for making thebaine and an acid salt of thebaine are disclosed herein. In one embodiment, an acid salt of thebaine is made from codeinone or an acid salt of one or more of the following: 8-methoxy-Δ6-dihydrothebaine, codeinone dimethyl ketal, and neopinone dimethyl ketal.
Claims49
A method for making thebaine, comprising the steps of:
- (a) heating a reaction mixture comprising an acid salt of 8-methoxy-Δ6-dihydrothebaine and an acid at a temperature and for a time sufficient to make methanol and an acid salt of thebaine;
- (b) distilling the methanol;
- and
- (c) neutralizing the acid salt of thebaine with a base.
1 more element
A method for making thebaine comprising the steps of:
- (a) heating a reaction mixture comprising an acid salt of codeinone dimethyl ketal and an acid at a temperature and for a time sufficient to make methanol and an acid salt of thebaine;
- (b) distilling the methanol;
- and
- (c) neutralizing the acid salt of thebaine with a base.
1 more element
A method for making thebaine comprising the steps of:
- (a) heating a reaction mixture comprising an acid salt of neopinone dimethyl ketal and an acid at a temperature and for a time sufficient to make methanol and an acid salt of thebaine;
- (b) distilling the methanol;
- and
- (c) neutralizing the acid salt of thebaine.
1 more element
A method for making thebaine comprising the steps of:
- (a) heating a first reaction mixture comprising an acid salt of codeinone, trimethyl orthoformate, methanol, and an acid at about the reaction mixture's boiling point to provide a second reaction mixture;
- (b) distilling substantially all of the methanol from the second reaction mixture to provide a third reaction mixture;
- (c) heating the third reaction mixture at a temperature and for a time sufficient to make methanol and an acid salt of thebaine;
- and
- (d) neutralizing the acid salt of thebaine with a base.
2 more elements
Dependencies are inferred from the claim text.