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US 6,958,347 B2Granted
Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists
AssigneePfizer Inc.
InventorMarlys Hammond
Life of this patent
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Abstract
The present invention provides NPY-5 receptor antagonists having a Formula (I) Methods and pharmaceutical compositions useful for treating diseases, conditions and/or disorders modulated by the above NPY-5 receptor antagonists are also provided.
Claims12
A compound of Formula (I)
- wherein
- R1 is hydrogen or (C1-C4)alkyl;
- R2 is hydrogen, —C(O)R2a, —C(O)—(CH2)n—R2b, or —(CH2)m—R2c, where n is 0, 1 or 2, m is 0, 1, 2 or 3, R2a is (C1-C4)alkyl or halo-substituted (C1-C4)alkyl, and R2b and R2c are —NH(C1-C4)alkyl, —N((C1-C4)alkyl)2, pyridinyl, hydroxy(C1-C4)alkyl, phenyl, or piperidinyl;
- R3 is (C1-C6)alkyl;
- and
- X is carbonyl or methylene;
- a pharmaceutically acceptable salt thereof, a prodrug of said compound or said salt, or a solvate or hydrate of said compound, said salt or said prodrug.
4 more elements
Dependencies are inferred from the claim text.