4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein

A hetero-tetrahydroquinoline according to the formula:

• in which A represents a radical of the formula:
• and wherein
• D represents aryl having 6 to 10 carbon atoms, which is optionally substituted one or more times by phenyl, nitro, halogen, trifluoromethyl, trifluoromethoxy,
• or
• represents a radical of the formula:
• in which
• R5, R6 and R9 independently represent cycloalkyl having 3 to 6 carbon atoms, or aryl having 6 to 10 carbon atoms,
• which are optionally substituted up to 5 times by identical or different substituents from the group consisting of halogen, trifluoromethyl, nitro, hydroxyl, cyano, carboxyl, trifluoromethoxy, and
• straight-chain or branched acyl having up to 6 carbon atoms, straight-chain or branched alkyl having up to 6 carbon atoms, straight-chain or branched alkylthio having up to 6 carbon atoms, straight-chain or branched alkylalkoxy having up to 6 carbon atoms, straight-chain or branched alkoxy having up to 6 carbon atoms or straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, aryl having 6 to 10 carbon atoms, trifluoromethyl-substituted aryl having 6 to 10 carbon atoms, radicals of the formula —OR10, radicals of the formula —SR11, radicals of the formula —SO2R12 and radicals of the formula:
• —NR13R14,
• in which
• R10, R11 and R12 represent aryl having 6 to 10 carbon atoms which is substituted up to 2 times by identical or different substituents selected from the group consisting of phenyl, halogen and straight-chain or branched alkyl having up to 6 carbon atoms;
• R13 and R14 represent hydrogen, phenyl, or straight-chain or branched alkyl having up to 6 carbon atoms;
• R7 represents hydrogen or halogen, and
• R8 represents hydrogen, halogen, azido, trifluoromethyl, hydroxyl, trifluoromethoxy, straight-chain or branched alkoxy having up to six carbon atoms, straight-chain or branched alkyl having up to six carbon atoms, or a radical of the formula —NR15R16,
• in which
• R15 and R16 are identical or different and represent hydrogen, phenyl, or
• straight-chain or branched alkyl having up to 6 carbon atoms,
• or
• R7 and R8 together form a radical of the formula ═O or ═NR17,
• in which
• R17 represents hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, straight-chain or branched alkoxy having up to 6 carbon atoms or straight-chain or branched acyl having up to 6 carbon atoms,
• L represents a straight-chain or branched alkylene having up to 8 carbon atoms or straight-chain or branched alkenylene chain having up to 8 carbon atoms, each of which alkylene or alkenylene are optionally substituted up to 2 times by hydroxyl;
• T and X are identical or different and represent a straight-chain or branched alkylene chain having up to 8 carbon atoms,
• or
• T or X represents a bond;
• V represents an oxygen or sulfur atom or represents an —NR18 group,
• in which
• R18 represents hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms or phenyl,
• E represents cycloalkyl having 3 to 8 carbon atoms, or
• represents straight-chain or branched alkyl having up to 8 carbon atoms which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or hydroxyl;
• or
• represents phenyl, which is optionally substituted by halogen or trifluoromethyl;
• and
• R19 represents hydrogen;
• or represents cycloalkyl having 3 to 7 carbon atoms;
• or
• represents straight-chain or branched silylalkyl having up to 8 carbon atoms;
• or represents straight-chain or branched alkyl having up to 8 carbon atoms,
• which alkyl is optionally substituted by hydroxyl;
• or straight-chain or branched alkoxy having up to 6 carbon atoms;
• a radical of the formula —OR22;
• or phenyl, which phenyl is optionally substituted by halogen, nitro, trifluoromethyl, trifluoromethoxy, phenyl or tetrazole-substituted phenyl;
• in which R22 represents straight-chain or branched acyl having up to 4 carbon atoms or benzyl;
• or
• R19 represents straight-chain or branched acyl having up to 20 carbon atoms or benzoyl which is optionally substituted by halogen, trifluoromethyl, nitro or trifluoromethoxy, or
• represents straight-chain or branched fluoroacyl having up to 8 carbon atoms and 9 fluorine atoms
• or a salt of said compound or or an N-oxide of said compound or said salt.