Thiazolopyrimidines and their use as modulators of chemokine receptor activity

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• wherein R represents a hydrogen atom, or a group —NR4R5;
• R4 and R5 each independently represent a hydrogen atom, or a 4-piperidinyl, C3-C6 cycloalkyl or C1-C8 alkyl group, which latter two groups may be optionally substituted by one or more substituent groups independently selected from halogen atoms and —NR6R7, —CONR6R7, —OR8, —COOR8, —NR9COR10, —SR11, —SO2R11, —SO2NR6R7, —NR9SO2R10, morpholinyl, C1-C4 alkyl, C3-C6 cycloalkyl, tetrahydrofuranyl aryl and heteroaryl groups, the aryl and heteroaryl groups being optionally substituted by one or more substituents independently selected from halogen atoms and cyano, nitro, —NR6R7, —CONR6R7, —OR8, —NR9COR10, —SO2NR6R7, —NR9SO2R10, C1-C6 alkyl and trifluoromethyl groups,
• or R4 and R5 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system, which ring system may be optionally substituted by one or more substituent groups independently selected from:
• —NR6R7, —CONR6R7, —OR8, —COOR8, —NR9COR10, and C1-C6 alkyl optionally substitued by one or more substituents independently selected from halogen atoms and —NR11R12 and —OR8 groups,
• R1 represents a C1-C8 alkyl group substituted by a five-membered heterocycle;
• R2 and R3 each independently represent a hydrogen atom, or a C3-C7 carbocyclic, C1-C8 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group, the latter four groups may be optionally substituted by one or more substituent groups independently selected from:
• halogen atoms, —NR6R7, —CONR6R7, —OR8, —COOR8, —NR9COR10, —SR11, —SO2R11, —SO2NR6R7, —NR9SO2R10 or
• a 3-8 membered ring optionally containing one or more atoms selected from O, S, NR9 and itself optionally substituted by C1-3-alkyl, halogen,
• R8 represents hydrogen, C1-C6 alkyl or a phenyl group the latter two of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, —OR14 and —NR15R16, —CONR15R16, —NR15COR16, —SO2NR15R16, NR15SO2R16
• R6 and R7 independently represent a hydrogen atom or a C1-C6 alkyl or phenyl group the latter two of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, —OR14 and —NR15R16, —CONR15R16, —NR15COR16, —SO2NR15R16, NR15SO2R16 or
• R6 and R7 together with the nitrogen atom to which they are attached form a 4- to 7-membered saturated heterocyclic ring system optionally comprising a further heteroatom selected from oxygen and nitrogen atoms, which ring system may be optionally substituted by one or more substituent groups independently selected from phenyl, —OR 14, —COOR14, —NR15R16, —CONR15R16, —NR15COR16, —SO2NR15R16, NR15SO2R16 or C1-C6 alkyl, itself optionally substituted by one or more substituents independently selected from halogen atoms and —NR15R16 and —OR7 groups,
• R11 represents a hydrogen atom or a C1-C6, or phenyl group, each of which may be optionally substituted by one or more substituent groups independently selected from halogen atoms, phenyl, —OR17 and —NR15R16, and
• R9, R10, R12, R13, R14, R15, R16, and R17 independently represent a hydrogen atom or a C1-C6, alkyl, or a phenyl group.