Bradykinin receptor antagonists

A compound of formula I

• wherein
• R1 and R2 independently are C1-C4alkyl or, together with the N-atom to which they are attached, represent a 5 to 7 membered heterocyclic ring;
• (a) R3 and R4 together are ethylene and m is 2;
• or
• (b) R3 is H, C1-C4alkyl, C5-C7cycloalkyl or phenyl-C1-C4alkyl, R4 is H and m is 1 or 2 or 3;
• n is zero ro 1;
• and
• R5 is —X—R6or —N(R7)R8, wherein
• X is
• R6 is C1-C4alkyl, C3-C4alkenyl, C3-C4alkinyl, C1-C4(alkoxyalkyl), C1-C4(carboxyalkyl), a C5-C7heterocyclic group or phenyl-C1-C4alkyl;
• R7 is amino-C2-C4alkyl or mono- or di-(C1-C5alkyl)amino-C2-C5alkyl, and
• R8 is H, C1-C4alkyl or has the meanings as given for R7;
• and salts thereof.

A compound having the formula

• wherein
• R5A is —XA—R6A or —N(R7A)R8A, wherein
• XA is piperidinylene or piperazinylene,
• R6A is H, C1-C4alkyl, C3-C4alkenyl, C3-C4alkinyl, C1-C4(alkoxyalkyl), C1-C4(carboxyalkyl), a C5-C7heterocyclic group or phenyl-C1-C4alkyl;
• R7A is amino-C2-C4alkyl or mono- or di-(C1-C5alkyl)amino-C2-C5alkyl, and
• R8A is H, C1-C4alkyl or has the meanings as given for R7A;
• X1 is a divalent group of formula IA′
• wherein
• n is zero or 1;
• X3 is CH or N;
• (a) X4 is a direct bond, R3A and R4A together are ethylene and m is 2:
• or
• (b) X4 is a direct bond, R3A is H, C1-C4alkyl, which may be unsubstituted or substituted by halogen, C3-C6cycloalkyl or aryl, C3-C6cycloalkyl, C3-C6alkenyl, C3-C6alkinyl, C7-C10aralkyl, which may be unsubsbtuted or substituted by halogen, methoxy, nitro or C1-C4alkyl which may be unsubstituted or substituted by halogen, or C6-C9heteroaralkyl, which may be unsubstituted or substituted by C1-C4alkyl, R4A is H and m is 1 or 2 or 3;
• or
• (c) X4 is —CH(R12)—, R3A is H and R4A and R12 together are propylene and m is 1, or ethylene and m is 2;
• X2 is a divalent group of formula IA″
• wherein
• X3 is CH or N;
• and
• R11 is C1-C4alkyl, C3-C6cycloalkyl or —NR1AR2A, wherein
• R1A and R2A independently are C1-C4alkyl or, together with the N-atom to which they are attached, represent a 5 to 7 membered heterocyclic ring;
• and
• R9 and R10 independently are a phenyl or pyridine ring, both of which may be unsubstituted or substituted by one or more halogen atoms;
• and salts thereof.