Polycyclic α-amino-ε-caprolactams and related compounds

A compound of formula II:

• wherein
• W is a substituted ε-caprolactam selected from the group consisting of:
• wherein
• ring A, together with the atoms of the ε-caprolactam to which it is attached, forms a carbocyclic or heterocyclic ring selected from the group consisting of:
• A) aryl having from 6 to 14 ring carbon atoms substituted with from 1 to 5 substituents selected from the group consisting of:
• 1) acyloxy selected from alkyl-C(O)O—, substituted alkyl —C(O)O—, cycloalkyl-C(O)O—, substituted cycloalkyl-C(O)O—, aryl-C(O)O—, heteroaryl-C(O)O—, and heterocyclic-C(O)O— wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein cycloalkyl is defined in B herein;
• wherein substituted cycloalkyl is defined in C herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 2) hydroxy;
• 3) acyl selected from alkyl-C(O)—, substituted alkyl-C(O)—, cycloalkyl-C(O)—, substituted cycloalkyl-C(O)—, aryl-C(O)—, heteroaryl-C(O)— and heterocyclic-C(O)— wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein cycloalkyl is defined in B herein;
• wherein substituted cycloalkyl is defined in C herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 4) alkyl as defined in R herein;
• 5) alkoxy having the formula alkyl-O— wherein alkyl is defined in R herein;
• 6) alkenyl as defined in T herein;
• 7) alkynyl as defined in V herein;
• 8) substituted alkyl as defined in S herein;
• 9) substituted alkoxy of the formula substituted alkyl-O— where substituted alkyl is as defined in S herein;
• 10) substituted alkenyl as defined in U herein;
• 11) substituted alkynyl as defined in W herein;
• 12) amino having the formula —NH2—;
• 13) substituted amino having the formula —N(R)2 where each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, cycloalkyl, substituted cycloalkyl, heteroaryl, heterocyclic and where both R groups are joined to form a heterocyclic group;
• wherein alkyl is defined in R herein;
• substituted alkyl is defined in S herein;
• wherein alkenyl is defined in T herein;
• wherein substituted alkenyl is defined in U herein;
• wherein alkynyl is defined in V herein;
• wherein substituted alkynyl is defined in W herein;
• wherein aryl is defined in A herein;
• wherein cycloalkyl is defined in B herein;
• wherein substituted cycloalkyl is defined in C herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 14) aminoacyl having the formula —NRC(O)R wherein each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl or heterocyclic;
• wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 15) acylamino having the formula —C(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic or where both R groups are joined to form a heterocyclic group;
• wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 16) alkaryl of the formula -alkylene-aryl having 1 to 8 carbon atoms in the alkylene moiety wherein aryl is defined in A herein and alkylene is a divalent alkyl where alkyl is defined in R herein;
• 17) aryl as defined in A herein;
• 18) aryloxy having the formula -aryl-O wherein aryl is defined in A herein;
• 19) azido;
• 20) carboxyl;
• 21) carboxylalkyl having the formula —C(O)Oalkyl and —C(O)O— substituted alkyl wherein alkyl as defined in R herein and substituted alkyl is defined in S herein;
• 22) cyano;
• 23) halo selected from fluoro, chloro, bromo and iodo;
• 24) nitro;
• 25) heteroaryl as defined in F herein;
• 26) heterocyclic as defined in G herein;
• 27) aminoacyloxy having the formula —NRC(O)OR wherein each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl or heterocyclic;
• wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 28) oxyacylamino having the formula —OC(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic wherein alkyl is defined in R herein;
• wherein substituted alkyl is defined in S herein;
• wherein aryl is defined in A herein;
• wherein heteroaryl is defined in F herein;
• and wherein heterocyclic is defined in G herein;
• 29) thioalkoxy having the formula —S-alkyl, wherein alkyl as defined in R herein;
• 30) substituted thioalkoxy having the formula —S-substituted alkyl, wherein substituted alkyl is defined in S herein;
• 31) thioaryloxy having the formula aryl-S— wherein aryl is defined in A herein;
• 32) thioheteroaryloxy having the formula heteroaryl-S— wherein heteroaryl is defined F herein;
• 33) —SO-alkyl wherein alkyl is defined in R herein;
• 34) —SO-substituted alkyl wherein substituted alkyl:
• is defined in S herein;
• 35) —SO-aryl wherein aryl is defined in A herein;
• 36) —SO-heteroaryl wherein heteroaryl is defined in F herein;
• 37) —SO2-alkyl wherein alkyl is defined in R herein;
• 38) —SO2-substituted alkyl wherein substituted alkyl is defined in S herein;
• 39) —SO2-aryl wherein aryl is defined in A herein;
• 40) —SO2-heteroaryl wherein heteroaryl is defined in F herein;
• and
• 41) trihalomethyl wherein halo is defined in A23 herein;
• B) cycloalkyl of from 3 to 12 carbon atoms;
• C) substituted cycloalkyl having 3 to 12 carbon atoms and from 1 to 5 substituents selected from the group consisting of:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;.
• 5) cycloalkenyl as defined in D herein;
• 6) substituted cycloalkenyl as defined in E herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) oxyacylamino as defined in A28 herein;
• 15) cyano;
• 16) halogen wherein halo is defined in A23 herein;
• 17) hydroxyl;
• 18) carboxyl;
• 19) carboxylalkyl as defined in A21 herein;
• 20) keto having the formula ═O;
• 21) thioketo having the formula ═S;
• 22) thiol having the formula —SH;
• 23) thioalkoxy as defined in A29 herein;
• 24) substituted thioalkoxy as defined in A30 herein;
• 25) aryl as defined in A herein;
• 26) aryloxy as defined in A18 herein;
• 27) heteroaryl as defined in F herein;
• 28) heteroaryloxy having the formula —O-heteroaryl wherein heteroaryl is defined in F herein;
• 29) heterocyclic as defined in G herein;
• 30) heterocyclooxy having the formula —O-heterocyclic wherein heterocyclic is defined in G herein;
• 31) hydroxyamino;
• 32) alkoxyamino wherein alkoxy is defined in A5 herein;
• 33) nitro;
• 34) —SO-alkyl as defined in A33 herein;
• 35) —SO-substituted alkyl as defined in A34 herein;
• 36) —SO-aryl as defined in A35 herein;
• 37) —SO-heteroaryl as defined in A36 herein;
• 38) —SO2-alkyl as defined in A37 herein;
• 39) —SO2-substituted alkyl as defined in A38 herein;
• 40) —SO2-aryl as defined in A39 herein;
• and
• 41) —SO2-heteroaryl as defined in A40 herein;
• D) cycloalkenyl of from 4 to 8 carbon atoms;
• E) substituted cycloalkenyl having from 4 to 8 carbon atoms and from 1 to 5 substituents selected from the group consisting of:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;
• 5) cycloalkenyl as defined in D herein;
• 6) substituted cycloalkenyl as defined in E herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) oxyacylamino as defined in A28 herein;
• 15) cyano;
• 16) halogen wherein halo is defined in A23 herein;
• 17) hydroxyl;
• 18) carboxyl;
• 19) carboxylalkyl as defined in A21 herein;
• 20) keto as defined in C20 herein;
• 21) thioketo as defined in C21 herein;
• 22) thiol as defined in C22 herein;
• 23) thioalkoxy as defined in A29 herein;
• 24) substituted thioalkoxy as defined in A30 herein;
• 25) aryl as defined in A herein;
• 26) aryloxy as defined in A18 herein;
• 27) heteroaryl as defined in F herein;
• 28) heteroaryloxy as defined in C28 herein;
• 29) heterocyclic as defined in G herein;
• 30) heterocyclooxy as defined in C30 herein;
• 31) hydroxyamino;
• 32) alkoxyamino as defined in C32 herein;
• 33) nitro;
• 34) —SO-alkyl as defined in A33 herein;
• 35) —SO-substituted alkyl as defined in A34 herein,
• 36) —SO-aryl as defined in A35 herein;
• 37) —SO-heteroaryl as defined in A36 herein;
• 38) —SO2-alkyl as defined in A37 herein;
• 39) —SO2-substituted alkyl as defined in A38 herein;
• 40) —SO2-aryl as defined in A39 herein;
• and
• 41) —SO2-heteroaryl as defined in A40 herein;
• F) heteroaryl of from 1 to 15 ring carbon atoms and 1 to 4 ring heteroatoms selected from oxygen, nitrogen and sulfur, substituted with from 1 to 5 substituents selected from:
• 1) acyloxy as defined in A1 herein;
• 2) hydroxy;
• 3) acyl as defined in A3 herein;
• 4) alkyl as defined in R herein;
• 5) alkoxy as defined in A5 herein;
• 6) alkenyl as defined in T herein;
• 7) alkynyl as defined in V herein;
• 8) substituted alkyl as defined in S herein;
• 9) substituted alkoxy as defined in A9 herein;
• 10) substituted alkenyl as defined in U herein;
• 11) substituted alkynyl as defined in W herein;
• 12) amino as defined in A12 herein;
• 13) substituted amino as defined in A13 herein;
• 14) aminoacyl as defined in A14 herein;
• 15) acylamino as defined in A15 herein;
• 16) alkaryl as defined in A16 herein;
• 17) aryl as defined in A herein;
• 18) aryloxy as defined in A18 herein;
• 19) azido;
• 20) carboxyl;
• 21) carboxylalkyl as defined in A21 herein;
• 22) cyano;
• 23) halo as defined in A23 herein;
• 24) nitro;
• 25) heteroaryl as defined in F herein;
• 26) heterocyclic as defined in G herein;
• 27) aminoacyloxy as defined in A27 herein;
• 28) oxyacylamino as defined in A28 herein;
• 29) thioalkoxy as defined in A29 herein;
• 30) substituted thioalkoxy as defined in A30 herein ;
• 31) thioaryloxy as defined in A31 herein;
• 32) thioheteroaryloxy as defined in A32 herein;
• 33) —SO-alkyl as defined in A33 herein;
• 34) —SO-substituted alkyl as defined in A34 herein;
• 35) —SO-aryl as defined in A35 herein;
• 36) —SO-heteroaryl as defined in A36 herein;
• 37) —SO2-alkyl as defined in A37 herein;
• 38) —SO2-substituted alkyl as defined in A38 herein;
• 39) —SO2-aryl as defined in A39 herein;
• 40) —SO2-heteroaryl as defined in A40 herein;
• and
• 41) trihalomethyl as defined in A41 herein;
• G) heterocyclic of from 1 to 15 ring carbon atoms and from 1 to 4 ring atoms selected from nitrogen, sulfur and oxygen, substituted with from 1 to 5 substituents selected from:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;
• 5) cycloalkenyl as defined in D herein;
• 6) substituted cycloalkenyl as defined in E herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) oxyacylamino as defined in A28 herein;
• 15) cyano;
• 16) halogen wherein halo is defined in A23 herein;
• 17) hydroxyl;
• 18) carboxyl;
• 19) carboxylalkyl as defined in A21 herein;
• 20) keto as defined in C20 herein;
• 21) thioketo as defined in C21 herein;
• 22) thiol as defined in C22 herein;
• 23) thioalkoxy as defined in A29 herein;
• 24) substituted thioalkoxy as defined in A30 herein;
• 25) aryl as defined in A herein;
• 26) aryloxy as defined in A18 herein;
• 27) heteroaryl as defined in F herein;
• 28) heteroaryloxy as defined in C28 herein;
• 29) heterocyclic as defined in G herein;
• 30) heterocyclooxy as defined in C30 herein;
• 31) hydroxyamino;
• 32) alkoxyamino as defined in C32 herein;
• 33) nitro;
• 34) —SO-alkyl as defined in A33 herein;
• 35) —SO-substituted alkyl as defined in A34 herein;
• 36) —SO-aryl as defined in A35 herein;
• 37) —SO-heteroaryl as defined in A36 herein;
• 38) —SO2-alkyl as defined in A37 herein;
• 39) —SO2-substituted alkyl as defined in A38 herein;
• 40) —SO2-aryl as defined in A39 herein;
• and
• 41) —SO2-heteroaryl as defined in A40 herein;
• ring B, together with the atoms of the ε-caprolactam to which it is attached, forms a carbocyclic or heterocyclic ring selected from the group consisting of:
• H) aryl as defined in A herein;
• I) cycloalkyl as defined in B herein;
• J) substituted cycloalkyl as defined in C herein;
• K) cycloalkenyl as defined in D herein;
• L) substituted cycloalkenyl as defined in E herein;
• M) heteroaryl as defined in F herein;
• and
• N) heterocyclic as defined in G herein;
• ring C, together with the atoms of the ε-caprolactam to which it is attached, forms a heteroaryl as defined in F herein or heterocyclic ring as defined in G herein;
• R1 is selected from the group consisting of:
• O) hydrogen;
• and
• P) an amino-blocking group being any group, bound to an amino group, which prevents undesired reactions from occurring at the amino group and which may be removed by conventional chemical and/or enzymatic procedures to reestablish the amino group;
• R3 is selected from the group consisting of:
• Q) hydrogen;
• [R) alkyl as defined in R herein;
• S) substituted alkyl as defined in S herein;
• T) alkenyl as defined in T herein;
• U) substituted alkenyl as defined in U herein;
• V) alkynyl as defined in as defined in V herein;
• W) substituted alkynyl as defined in W herein;]
• R) alkyl of from 1 to 20 carbon atoms;
• S) substituted alkyl of from 1 to 20 carbon atoms having from 1 to 5 substituents selected from:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;
• 5) cycloalkenyl as defined in D herein;
• 6) substituted cycloalkenyl as defined in E herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) oxyacylamino as defined in A28 herein;
• 15) cyano;
• 16) halogen wherein halo is defined in A23 herein;
• 17) hydroxyl;
• 18) carboxyl;
• 19)carboxylalkyl as defined in A21 herein;
• 20) keto as defined in C20 herein;
• 21) thioketo as defined in C21 herein;
• 22) thiol as defined in C22 herein;
• 23) thioalkoxy as defined in A29 herein;
• 24) substituted thioalkoxy as defined in A30 herein;
• 25) aryl as defined in A herein;
• 26) aryloxy as defined in A18 herein;
• 27) heteroaryl as defined in F herein;
• 28) heteroaryloxy as defined in C28 herein;
• 29) heterocyclic as defined in G herein;
• 30) heterocyclooxy as defined in C30 herein;
• 31) hydroxyamino;
• 32) alkoxyamino as defined in C32 herein;
• 33) nitro;
• 34) —SO-alkyl as defined in A33 herein;
• 35) —SO-substituted alkyl as defined in A34 herein;
• 36) —SO-aryl as defined in A35 herein;
• 37) —SO-heteroaryl as defined in A36 herein;
• 38) —SO2-alkyl as defined in A37 herein;
• 39) —SO2-substituted alkyl as defined in A38 herein;
• 40) —SO2-aryl as defined in A39 herein;
• and
• 41) —SO2-heteroaryl as defined in A40 herein;
• T) alkenyl of from 2 to 10 carbon atoms and 1-2 sites of alkenyl unsaturation;
• U) substituted alkenyl having from 1 to 3 substituents selected from the group consisting of:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;
• 5) cycloalkoxy wherein alkoxy is defined in A5 herein;
• 6) substituted cycloalkoxyl wherein substituted alkoxy is defined in A9 herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) cyano;
• 15) halogen wherein halo is defined in A23 herein;
• 16) hydroxyl;
• 17) carboxyl;
• 18) carboxylalkyl as defined in A21 herein;
• 19) keto as defined in C20 herein;
• 20) thioketo as defined in C21 herein;
• 21) thiol as defined in C22 herein;
• 22) thioalkoxy as defined in A29 herein;
• 23) substituted thioalkoxy as defined in A30 herein;
• 24) aryl as defined in A herein;
• 25) heteroaryl as defined in F herein;
• 26) heterocyclic as defined in G herein;
• 27) heterocyclooxy as defined in C30 herein;
• 28) nitro;
• 29) —SO-alkyl as defined in A33 herein;
• 30) —SO-substituted alkyl as defined in A34 herein;
• 31) —SO-aryl as defined in A35 herein;
• 32) —SO-heteroaryl as defined in A36 herein;
• 33) —SO2-alkyl as defined in A37 herein;
• 34) —SO2-substituted alkyl as defined in A38 herein;
• 35) —SO2-aryl as defined in A39 herein;
• and
• 36) —SO2-heteroaryl as defined in A40 herein;
• V) alkynyl of from 2 to 10 carbon atoms and from 1-2 sites of alkynyl unsaturation;
• W) substituted alkynyl of from 1 to 3 substituents selected from:
• 1) alkoxy as defined in A5 herein;
• 2) substituted alkoxy as defined in A9 herein;
• 3) cycloalkyl as defined in B herein;
• 4) substituted cycloalkyl as defined in C herein;
• 5) cycloalkoxy as defined in U5 herein;
• 6) substituted cycloalkoxyl as defined in U6 herein;
• 7) acyl as defined in A3 herein;
• 8) acylamino as defined in A15 herein;
• 9) acyloxy as defined in A1 herein;
• 10) amino as defined in A12 herein;
• 11) substituted amino as defined in A13 herein;
• 12) aminoacyl as defined in A14 herein;
• 13) aminoacyloxy as defined in A27 herein;
• 14) cyano;
• 15) halogen wherein halo is defined in A23 herein;
• 16) hydroxyl;
• 17) carboxyl;
• 18) carboxylalkyl as defined in A21 herein;
• 19) keto as defined in C20 herein;
• 20) thioketo as defined as C21 herein;
• 21) thiol as defined as C22 herein;
• 22) thioalkoxy as defined in A29 herein;
• 23) substituted thioalkoxy as defined in A30 herein;
• 24) aryl as defined in A herein;
• 25) heteroaryl as defined in F herein;
• 26) heterocyclic as defined in G herein;
• 27) heterocyclooxy as defined in C30 herein;
• 28) nitro;
• 29) —SO-alkyl as defined in A33 herein;
• 30) —SO-substituted alkyl as defined in A34 herein;
• 31) —SO-aryl as defined in A35 herein;
• 32) —SO-heteroaryl as defined in A36 herein;
• 33) —SO2-alkyl as defined in A37 herein;
• 34) —SO2-substituted alkyl as defined in A38 herein;
• 35—SO2-aryl as defined in A39 herein;
• and
• 36) —SO2-heteroaryl as defined in A40 herein;
• X) acyl as defined in A3 herein;
• Y) aryl as defined in A herein;
• Z) cycloalkyl as defined in B herein;
• AA) substituted cycloalkyl as defined in C herein;
• BB) cycloalkenyl as defined in D herein;
• CC) substituted cycloalkenyl as defined in E herein;
• DD) heteroaryl as defined in F herein;
• and
• EE) heterocyclic as defined in G herein;
• each R4 is independently selected from the group consisting of:
• FF) alkyl as defined in R herein;
• GG) substituted alkyl as defined in S herein;
• HH) alkenyl as defined in T herein;
• II) substituted alkenyl as defined in U herein;
• JJ) alkynyl as defined in V herein;
• KK) substituted alkynyl as defined in W herein;
• each R4 is independently selected from the group consisting of:
• FF) alkyl as defined in R herein;
• GG) substituted alkyl as defined in S herein;
• HH) alkenyl as defined in T herein;
• II) substituted alkenyl as defined in U herein;
• JJ) alkynyl as defined in V herein;
• KK) substituted alkynyl as defined in W herein;
• LL) aryl as defined in A herein;
• MM) cycloalkyl as defined in B herein;
• NN) substituted cycloalkyl as defined in C herein;
• OO) cycloalkenyl as defined in D herein;
• PP) substituted cycloalkenyl as defined in E herein;
• QQ) heteroaryl as defined in F herein;
• and
• RR) heterocyclic as defined in G herein;
• m is an integer from 0 to 2;
• or salts thereof.

A compound selected from the group consisting of:

• 5-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-amino)-7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-(2-methylpropyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-amino)-7-(methoxycarbonymethyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-methoxcarbonylmethyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-amino)-7-(3,3-dimethyl-butanonyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-(3,3-dimethyl-2-butanonyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-cyclopropymethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-(2′,2′,2′-trifluoroethyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-cyclohexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-hexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-10-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-13-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-7-methyl-1,2,3,4,5,7-hexahydro-6H-dicyclohexyl[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-7-methyl -5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-tert-leucinyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-tert-leucinyl)amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-10-fluoro-7-(methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-10-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-13-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-13-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-alaninyl)amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-alaninyl)amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-7-cyclopropylmethyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin6-one
• 5-(L-valinyl)amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-7-hexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-7-hexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-9-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-10-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-10-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(N-Boc-L-valinyl)amino-13-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-(L-valinyl)amino-13-fluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-9,13-difluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-amino-10,13-difluoro-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one
• 5-aminohexahydropyrido[a]benz[d]azepin-6-one
• 9-amino-5,6-Dihydro-4H-quino[8,1-ab][3]benzazepin-8(9H)-one
• 9-(N′-Boc-L-alaninyl)amino-5,6-Dihydro-4H-quino[8,1-ab][3]benzazepin-8(9H)-one
• 9-(N′-L-alaninyl)amino-5,6-dihydro-4H-quino[8,1-ab][3]benzazepin-8(9H)-one
• 7-amino-1,3,4,7,12,12a-hexahydropyrido[2,1-b][3]benzazepin-6(2H)-one
• 1-amino-4,5,6,7-tetrahydro-3,7-methano-3H-3-benzazepin-2(1H)-one
• 1-(N′-Boc-L-alaninyl)amino4,5,6,7-tetrahydro-3,7-methano-3H-3-benzazepin-2(1H)-one
• 1-(N′-L-alaninyl)amino4,5,6,7-tetrahydro-3,7-methano-3H-3-benzazepin-2(1H)-one or salts thereof.