Cationic polysaccharide compositions
AssigneeEfrat Biopolymers Ltd.
InventorAbraham J. Domb
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Abstract
The invention provides a polycation composition comprising a polysaccharide chain having an amount of saccharide units ranging from 2 to 2000, at least one oligoamine directly grafted to said polysaccharide chain per each segment of 5 saccharide units, wherein said oligoamine is selected from the group consisting of a linear, branched and cyclic alkyl amine having at least two amino groups, and at least one further grafted group selected from the group consisting of a hydrophobic and an amphiphilic group directly grafted to said polysaccharide chain per each segment of 50 saccharide units, wherein said hydrophobic or amphiphilic group includes an aliphatic chain of at least 4 carbons atoms.
Claims26
A polycation compound comprising:
- a) a natural or synthetic polysaccharide chain having an amount of saccharide ranging from 2 to 2000 saccharide units;
- b) at least one oligoamine grafted covalently to the polysaccharide chain per each segment of 5 saccharide units, wherein the oligoamine is a linear, branched or cyclic alkyl amine having at least two amino groups;
- and
- c) at least one further grafted group which is either a hydrophobic group or an amphiphilic group grafted covalently to the polysaccharide chain per each segment of 50 saccharide units, wherein the hydrophobic group or amphiphilic group includes an aliphatic chain of at least 4 carbon atoms.
A biodegradable polycation complex with a polyanion comprising:
- a) a natural or synthetic polysaccharide chain having an amount of saccharide ranging from 2 to 2000 saccharide units;
- b) at least one oligoamine grafted covalently to the polysaccharide chain per each segment of 5 saccharide units, wherein the oligoamine is a linear, branched or cyclic alkyl amine having at least two amino groups;
- and
- c) at least one further grafted group which is either a hydrophobic group or an amphiphilic group grafted covalently to the polysaccharide chain per each segment of 50 saccharide units, wherein the hydrophobic or amphiphilic group includes an aliphatic chain of at least 4 carbon atoms;
- and
- wherein the hydrophobic or amphiphilic group is complexed with an anionic macromolecule selected from the group consisting of polynucleic acids, proteins and polysaccharides that are anionic.
A porous matrix suitable as a scaffold for cell growth comprising a porous scaffold suitable for attachment of cells, wherein the scaffold is formed of a polycation composition comprising
- a) a polysaccharide chain having an amount of saccharide ranging from 2 to 2000 saccharide units;
- b) at least one oligoamine grafted covalently to the polysaccharide chain per each segment of 5 saccharide units, wherein the oligoamine is a linear, branched or cyclic alkyl amine having at least two amino groups;
- and
- c) at least one further grafted group which is either a hydrophobic group or an amphiphilic group grafted covalently to the polysaccharide chain per each segment of 50 saccharide units, wherein the hydrophobic group or amphiphilic group includes an aliphatic chain of at least 4 carbon atoms.
Dependencies are inferred from the claim text.