US 6,958,323 B2 · Uses of α-conotoxin peptides

Abstract

The present invention relates to the use of α-conotoxin peptides having the general formula Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Pro-Xaa5-Cys-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Cys (SEQ ID NO:1) for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma. In this formula, Xaa1 is des-Xaa1, Tyr, mono-iodo-Tyr or di-iodo-Tyr, Xaa2 is any amino acid, Xaa3 is any amino acid, Xaa4 is any amino acid, Xaa5 is any amino acid; Xaa6 is any amino acid, Xaa7 is any amino acid, Xaa8 is any amino acid, Xaa9 is des-Xaa9 or any amino acid, Xaa10 is des-Xaa10 or any amino acid, Xaa11 is des-Xaa11 or any amino acid and Xaa2 is des-Xaa12 or any amino acid. Disulfide linkages exist between the first and third cysteines and the second and fourth cysteines. Pro may be replaced with hydroxy-Pro. The C-terminus may contain a hydroxyl or an amide group, preferably an amide group.

Claims24

Dependent claims

A method for treating disorders regulated at α7 or α3β2 neuronal nicotinic acetylcholine receptors (nAChRs) which comprises administering to a patient in need of such treatment a therapeutically effective amount of an α-conotoxin peptide having the formula Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Leu-Asn-Asn-Pro-Asp-Tyr-Cys (SEQ ID NO:10).

Dependencies are inferred from the claim text.

Facts

Application

09/897,465Filed 3 Jul 2001 · division

Priority

31 Dec 1997

Published

US 2002/0022715 A121 Feb 2002

Granted

25 Oct 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 38/17
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from animals; from humans
A61K 38/08
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 5 to 11 amino acids
C07K 14/43504
From animals; from humans: from invertebrates
A61K 38/095
Peptides having 5 to 11 amino acids: oxytocins; Vasopressins; Related peptides

Family

Application60/070,153Us provisional application · filed 31 Dec 1997

Application60/080,588Us provisional application · filed 3 Apr 1998

Application09/219,446Parent of this division · filed 23 Dec 1998

US 2002/0022715 A1Pre-grant publication · published 21 Feb 2002

US 6,265,541 B1Parent of this division

US 6,958,323 B2This patent

From the US filing history. Foreign family members aren’t listed.

Uses of α-conotoxin peptides

Life of this patent

Uses of α-conotoxin peptides

Life of this patent

Abstract

Claims24