Organic reactions with CO generating materials
AssigneeBiotage AB
InventorsMats Larhed, Mathias Alterman, Yiqian Wan, Hallberg Anders, Nils-Fredrik Kaiser
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Abstract
The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.
Claims30
A method of performing a one-pot organic reaction, which includes carbon monoxide as reactant without the use of an external CO gas source, comprising
- preparing a reaction mixture containing a non-catalysing solid CO releasing compound which is a metal carbonyl of the general formula I,
- Mx(CO)y
- wherein M is a metal, x is an integer, y is an integer, a non-metal substrate compound and a metal catalyst;
- wherein the metal carbonyl is not complexed with or bonded to the non-metal substrate compound prior to preparing said reaction mixture;
- and
- exposing said reaction mixture to an energy source to release carbon monoxide from the CO releasing compound,
- wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound.
Dependencies are inferred from the claim text.