Therapeutic liposome composition and method
OwnerFrancis J. Martin, Samuel Zalipsky +1inventors
InventorsFrancis J. Martin, Samuel Zalipsky, Shi Kun Huang
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Abstract
A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.
Claims15
A method of administering an affinity moiety to a mammalian subject, comprising
- administering to the subject, liposomes with outer surfaces that contain (i) an affinity moiety effective to bind specifically to a target surface at which the therapy is aimed, and (ii) a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface, said hydrophilic polymer coating being made up of polymer chains which are covalently linked to surface lipid oomponents in the liposomes through releasable linkages, and
- allowing the administered liposomes to achieve a desired biodistribution,
- whereby said allowing is effective to cause release of a substantial portion of said linkages in the administered liposomes, thereby to expose the affinity moiety to the target surface.
A liposome composition for use in treating a subject with an affinity moiety capable of inhibiting binding of a first binding member, which is a pathogen or cell in the bloodstream, to a second binding member, which is a target cell or cell matrix, comprising
- liposomes having outer surfaces that contain (i) a hydrophilic polymer coating composed of polyethylene glycol chains that are covalently linked to surface lipid components in the liposomes through releasable linkages, and (ii) said affinity moiety bound to the outer surfaces of said liposomes, such that the affinity moiety is shielded by said hydrophilic polymer coating from interaction with such binding members and is exposed for interaction with such binding members when at least a portion of the hydrophilic polymer coating is released.
Dependencies are inferred from the claim text.