Polymorphic kinase anchor proteins and nucleic acids encoding the same
AssigneeSequenom, Inc.
InventorAndreas Braun
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Abstract
Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing disorders of signal transduction. Methods of determining susceptibility to morbidity and/or increased or early mortality are also provided.
Claims15
An isolated nucleic acid molecule, comprising a sequence of nucleotides that encodes a polypeptide of SEQ ID NO. 2, except that the Ile residue at position 646 of SEQ ID NO:
- 2 is replaced with Val, Leu or Phe.
A cell which comprises a heterologous nucleic acid that encodes the sequence of amino acids set forth in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.