Antithrombotic agents
AssigneeProvexis Limited
InventorAsim Kanti Dutta-Roy
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Abstract
Methods of prophylaxis or treatment of a disease state initiated by or characterized by platelet aggregation, that employ a fruit extract or active fraction thereof, are disclosed. In one embodiment, the fruit extract or active fraction thereof, is obtained from the fruit of plants of the families Solanaceae, Rutaceae, Cucurbitaceae, Rosaceae, Musaceae, Anacardiaceae, Bromeliaceae, Vitaceae, Arecaceae, Ericaceae and Lauraceae. Pharmaceutical compositions comprising a fruit extract or active fraction thereof having platelet aggregation inhibitory activity are also disclosed.
Claims11
A method for the prophylaxis treatment of a condition or disorder mediated by platelet aggregation, the method comprising administering to a patient in need of such treatment, a therapeutically effective amount of a fruit extract having platelet aggregation inhibiting activity, the fruit extract being a water soluble extract of tomato;
- wherein the extract contains an active fraction having active components that are capable of passing through an ultrafiltration filter having a molecular weight cut-off of 1000, the active fraction containing one or more nucleosides having platelet aggregation inhibiting activity;
- and wherein the extract has been prepared by a process comprising the steps of homogenizing the flesh of a tomato to form a homogenate and removing solids therefrom to give an aqueous extract.
Dependencies are inferred from the claim text.