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US 6,958,160 B1Granted
Self forming, thermodynamically stable liposomes and their applications
AssigneeBioZone Technologies, Inc.
InventorBrian Charles Keller
Life of this patent
Estimating the term…
Abstract
A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is below about 40 degrees C., and the acyl chains of the diacylglycerol-PEG are greater than or equal to 14 carbons in length. Such liposome suspensions are useful for a variety of purposes, including the delivery of therapeutic agents.
Claims10
A liposome comprising:
- one or more lipids where the total lipids have a Pa between about 0.84 and 0.88 and a Pv between about 0.88 and 0.93,
- where Pa is the packing parameter with respect to surface and Pv is the packing parameter with respect to volume,
- where one or more of the lipids is a diacylglycerol-PEG,
- where the melting point of the diacylglycerol-PEG is below about 40 degrees C., and
- where the acyl chains of the diacylglycerol-PEG are greater than or equal to 14 carbons in length.
2 more elements
The product of a process consisting essentially of:
- providing one or more lipids where the total lipids have a Pa between about 0.84 and 0.88 and a Pv between about 0.88 and 0.93, where Pa is the packing parameter with respect to surface and Pv is the packing parameter with respect to volume and where one or more of the lipids is a diacylglycerol-PEG having a melting point below about 40 degrees C. and also having acyl chains greater than or equal to 14 carbons in length, and
- combining the lipid or lipids with an aqueous solution at a temperature above the melting point of the lipid or lipids.
Dependencies are inferred from the claim text.