Immune modulation device for use in animals
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsKevor S. TenHuisen, Joel Rosenblatt, Ilya S. Koyfman
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Abstract
The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
Claims32
An immune modulation device that is suitable for use in modulating an immune response in animals, comprising:
- an impermeable biocompatible shell having an outer surface comprising a plurality of pores of suitable size to allow the ingress and egress of immune cells, said impermeable biocompatible shell having an interior lumen,
- a biocompatible fibrous scaffolding being disposed within said interior lumen, said fibrous scaffolding comprising textured yarn containing crimped fibers having crimp points, wherein the orientation of filaments in said crimped fiber changes angle at said crimp points;
- and
- an antigen disposed within said interior lumen.
Dependencies are inferred from the claim text.