Miniprotein ligands and other polypeptides and methods for making and using same
AssigneeBoard of Regents, The University of Texas System
InventorsRobert O. Fox, Alan D. Barrett, Xiuzhen Fan, Michael R. Holbrook
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Abstract
Disclosed are polypeptides which include an amino acid sequence corresponding to CCXXXCKEGXXC (SEQ ID NO:1). Also disclosed are methods for inhibiting the activity of a flavivirus or other virus by contacting the virus with a miniprotein ligand under conditions effective for the miniprotein ligand to bind to the virus. Methods for detecting a flavivirus or other virus in a sample by contacting the sample with a miniprotein ligand and determining whether the miniprotein ligand is bound to a flavivirus or other virus as also disclosed, as are methods of assessing a compound's usefulness in inhibiting the activity of a flavivirus or other virus.
Claims15
A polypeptide comprising an amino acid sequence of SEQ ID NO:
- 1, and wherein said polypeptide is capable of binding to a Domain III of a flavivirus.
Dependencies are inferred from the claim text.