Methods of enhancing radiation effects with metal nanoparticles
AssigneeNanoprobes, Inc.
InventorsJames F. Hainfeld, Daniel N. Slatkin
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Abstract
The present invention provides methods of using metal nanoparticles 0.5 to 400 nm in diameter to enhance the dose and effectiveness of x-rays or of other kinds of radiation in therapeutic regimes of ablating a target tissue such as tumor. The metal nanoparticles can be administered intravenously, intra-arterially, or locally to achieve specific loading in and around the target tissue. The metal nanoparticles can also be linked to chemical and/or biochemical moieties which bind specifically to the target tissue. The enhanced radiation methods can also be applied to ablate unwanted tissues or cells ex vivo.
Claims54
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells wherein said radiation is in the form of x-rays of about 1 KeV to about 25.000 KeV.
A method of ablating a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells wherein said radiation is in the form of x-rays of about 1 KeV to about 25.000 KeV.
A method of ablating a population of cells from a tissue in an animal comprising removing said tissue from said animal, admixing an amount of metal nanoparticles with said tissue ex vivo wherein said metal nanoparticles bind specifically to said population of cells, and irradiating said tissue to ablate said population of cells.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles comprise a surface layer material which comprises thioglucose.
A method of ablating a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles comprise a surface layer material which comprises thioglucose.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said nanoparticles are polyanions of metals complexed with quaternary ammonium salts.
A method of ablating a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said nanoparticles are polyanions of metals complexed with quaternary ammonium salts.
A method of enhancing the effects of radiation directed to a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles are administered to said animal in an amount to achieve a concentration in said tissue or said population of cells in the animal of at least about 0.1% metal by weight.
A method of ablating a tissue or a population of cells in an animal comprising administering an amount of metal nanoparticles to said animal wherein the size of the metal cores of said nanoparticles is in the range of 0.8 to 400 nm in diameter, and subsequently irradiating the animal with radiation directed to said tissue or said population of cells, wherein said metal nanoparticles are administered to said animal in an amount to achieve a concentration in said tissue or said population of cells in the animal of at least about 0.1% metal by weight.
Dependencies are inferred from the claim text.