US 6,951,958 B1 · Solid phase parallel synthesis of tertiary amines

Abstract

Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O—N bond using the following steps: a) reacting the hydroxylamine derivative with an alkylating agent or with a carbonyl compound to form an oxime intermediate. b) reacting the oxime intermediate with a reducing agent to produce an alkylated derivative c) reacting the alkylated derivative with an alkylating agent or a carbonyl compound in the presence of a reducing agent to produce a dialkylated derivative d) reacting the dialkylated derivative with an alkylating agent to produce a quaternized derivative e) reacting the quaternized derivative with a reagent causing cleavage of the O—N bond to produce a tertiary amine.

Claims34

Dependent claims

A method for preparing tertiary amines comprising:

sequential, exhaustive alkylation of a hydroxylamine derivative;
and,
cleavage of the O—N bond.

Dependencies are inferred from the claim text.

Facts

Application

10/049,669Filed 3 Aug 2000 · us provisional application

Priority

3 Aug 1999

Granted

4 Oct 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 239/20
Hydroxylamino compounds or their ethers or esters: having oxygen atoms of hydroxylamino groups etherified
C07C 209/40
By reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds: by reduction of hydroxylamino or oxyimino groups
C07C 211/17
Of a saturated carbon skeleton containing rings other than six-membered aromatic rings: containing only non-condensed rings
C07C 211/27
Of an unsaturated carbon skeleton containing at least one six-membered aromatic ring: having amino groups linked to the six-membered aromatic ring…

Solid phase parallel synthesis of tertiary amines

Life of this patent

Solid phase parallel synthesis of tertiary amines

Life of this patent

Abstract

Claims34