4-dedimethylaminotracycline derivatives
AssigneeCollaGenex Pharmaceuticals, Inc.
InventorsRobert A. Ashley, Joseph J. Hlavaka
Life of this patent
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Abstract
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
Claims11
A 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline compound having structure K
- wherein:
- R7, R8, and R9 taken together in each case, have the following meanings:
- R7
- R8
- R9
- hydrogen
- hydrogen
- amino (COL-308)
- hydrogen
- hydrogen
- palmitamide (COL-311).
A 6-demethyl-6-deoxy-4-de(dimethylamino)-tetracycline compound having structure K
- wherein R7 is hydrogen, R8 is hydrogen and R9 is amino (COL-308).
A 6-demethyl-6-deoxy-4-de(dimethylamino)-tetracycline compound having structure K
- wherein R7 is hydrogen, R8 is hydrogen and R9 is palmitamide (COL-311).
Dependencies are inferred from the claim text.