Pharmaceutical composition
AssigneeConnetics Australia Pty Ltd
InventorsTony Wai-Chiu So, Peter Paul Deo, Russell John Tait
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.
Claims21
A homogeneous aerosol formulation, said homogeneous aerosol formulation consisting essentially of:
- approximately 5% or greater by weight of minoxidil or a pharmaceutically acceptable salt thereof;
- an acid in an amount effective to solubilize the minoxidil or a pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid, and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof;
- a solvent of water and a lower alcohol wherein the ratio of water to alcohol is in a range of approximately 9:1 to 1:9 by volume;
- and a co-solvent of a polyhydric alcohol selected from 1,3-butylene glycol, polyethylene glycol, hexylene glycol, dipropylene glycol, glycerol or propylene glycol at less than approximately 10% by weight;
- wherein the final product of the homogeneous aerosol formulation is foam or a mousse.
A homogeneous aerosol formulation, said homogeneous aerosol formulation consisting essentially of:
- approximately 5% by weight of minoxidil or a pharmaceutically acceptable salt thereof;
- an acid in an amount effective to solubilise the minoxidil or pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid, and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof;
- and
- water, ethanol, and less than approximately 10% by weight of propylene glycol;
- wherein the ratio of water to alcohol is in a range of approximately 9:1 to 1:9 by volume;
- wherein the final product of the homogeneous aerosol formulation is a foam or a mousse.
A homogeneous aerosol formulation, said homogeneous aerosol formulation consisting essentially of:
- approximately 5% by weight of minoxidil or a pharmaceutically acceptable salt thereof;
- an acid in an amount effective to solubilise the minoxidil or pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid, and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof;
- water and ethanol, wherein the ratio of water to alcohol is in a range of approximately 9:1 to 1:9 by volume;
- cetyl alcohol, stearyl alcohol and polysorbate 60;
- and
- approximately 5% or less by weight of propylene glycol;
- wherein the final product of the homogeneous aerosol formulation is a foam or a mousse.
A homogeneous aerosol formulation, said aerosol formulation consisting essentially of:
- approximately 5% by weight of minoxidil or a pharmaceutically acceptable salt thereof;
- an acid in an amount effective to solubilise the minoxidil or pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid, and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof;
- water and ethanol, wherein the ratio of water to alcohol is in a range of approximately 9:1 to 1:9 by volume;
- cetyl alcohol, stearyl alcohol and polysorbate 60;
- approximately 5% or less by weight of propylene glycol;
- and
- an antioxidant,
- wherein the final product of the homogeneous aerosol formulation is a foam or a mousse.
Dependencies are inferred from the claim text.