Methods for sterilizing biological materials
AssigneeClearant, Inc.
InventorsShirley I. Miekka, Wilson Burgess, William N. Drohan, Yuri Griko, Martin J. MacPhee, David M. Mann
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Abstract
Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known as transmissible spongiform encephalopathies (TSEs) in mammals. These methods involve sterilizing biological materials with irradiation.
Claims70
A composition comprising at least one biological material and at least one stabilizer in an amount effective to preserve said biological material for sterilization with radiation, wherein said biological material is glassy or vitrified.
A composition comprising at least one biological material with residual solvent content, wherein the residual solvent content of said biological material is at a level effective to preserve said biological material for sterilization with radiation, wherein said biological material is glassy or vitrified.
A method for sterilizing a biological material that is sensitive to radiation, said method comprising
- adding to said biological material at least one stabilizer;
- and
- irradiating said biological material with radiation for a time effective to sterilize said biological material at a rate effective to sterilize and protect said biological material from said radiation, wherein said biological material is glassy or vitrified.
A method for sterilizing a biological material comprising residual solvent content, wherein said biological material is sensitive to radiation, said method comprising
- reducing the residual solvent content of said biological material;
- and
- irradiating said biological material with radiation for a time effective to sterilize said biological material at a rate effective to sterilize and protect said biological material from said radiation,
- wherein said residual solvent content of said biological material is reduced to a level effective to preserve said biological material and said biological material is glassy or vitrified.
Dependencies are inferred from the claim text.