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US 6,939,569 B1Granted
Medical device having anti-infective and contraceptive properties
AssigneeOxiBio, Inc.
InventorsTerrence R. Green, Jack Fellman
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AssigneeOxiBio, Inc.
InventorsTerrence R. Green, Jack Fellman
Estimating the term…
There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.
An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, said device comprising a solid polymeric matrix selected from the group selected from a two component elastomer formulation, room temperature vulcanization elastomers, thermoplastic polymers, and hydrogels, containing within the matrix solid particles of an oxidant-producing component comprising a reducing agent, an oxidizing agent consisting of anhydrous alkali iodine oxide salts, inorganic and organic peracids, iodine pentoxide, an oxidase enzyme, and combinations thereof, that, when wetted, causes the formation of an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir;
An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, comprising a solid polymeric matrix, comprising a solid polymeric matrix selected from the group consisting of room temperature vulcanization elastomers that contain within the matrix solid particles of an oxidant-producing component comprising an iodide salt and an oxidizing agent consisting of substrate oxidoreductases which, when allowed to contact oxidoreductase substrates in body fluids causes the formation of an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir;
An implantable anti-infective medical device selected from the group consisting of catheters, prostheses, shunts, stents, and leadwires, comprising a solid polymeric matrix selected from the group consisting of thermoplastic polymers and thermosetting polymers, containing within the matrix solid particles of a non-enzyme, oxidant-producing component comprising an oxidizing agent and an iodide salt which, when allowed to contact body fluids, generates an oxidant and sustained release of the thus-formed oxidant into and about the polymeric matrix so that the matrix serves as an anti-infective reservoir, wherein the oxidant is iodine generated at a quantity sufficient so that free-iodine concentration near a surface of the device should reach a level of at least 5 ppm.
Dependencies are inferred from the claim text.