Antithrombogenic membrane mimetic compositions and methods

A method for producing an antithrombotic membrane mimetic surface on a synthetic prosthesis, synthetic vascular graft, medical implant, medical device orheterograft tissue, said method comprising the steps of

• (a) providing a hydrated surface on at least one surface of a synthetic prosthesis, synthetic vascular graft, medical implant, heterograft tissue or medical device;
• (b) complexing at least one polyelectrolyte to the hydrated surface of step (a) to produce a polyelectrolyte-complexed surface;
• (c) coating the polyelectrolyte-complexed surface of step (b) with an amphiphilic polymer, wherein said amphiphilic polymer comprises alkyl groups of from about 8 to about 20 carbon atoms, to produce an alkylated hydrated surface;
• (d) providing at least one polymerizable functionalized phospholipid to the alkylated surface of step (c) and further fusing antithrombotic liposomes to the alkylated hydrated surface of step (c) to produce a stabilization surface;
• (e) photopolymerizing the at least one polymerizable functionalized phospholipid in the stabilization surface of step (d) to produce an antithrombotic membrane mimetic surface on the synthetic prosthesis, synthetic vascular graft, medical implant, medical device or heterograft tissue,
• whereby the synthetic prosthesis, synthetic vascular graft, medical implant or medical device is improved in biocompatibility over a synthetic prosthesis, synthetic vascular graft, medical implant or medical device lacking said antithrombotic membrane mimetic surface.