Methods for treatment of diabetes using a peptide analogues of insulin
AssigneeNeurocrine Biosciences, Inc.
InventorsAmitabh Gaur, Nicholas Ling, Paul J. Conlon
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Abstract
The present invention is directed toward peptide analogues of insulin B chain that are generally derived from peptides comprising residues 9 to 23 of the native B chain sequence. The analogues are altered from the native sequence at position 12, 13, 15 and/or 16, and may be additionally be altered at position 19 and/or other positions. Pharmaceutical compositions containing these peptide analogues are provided. The peptide analogues are useful for treating and inhibiting the development of diabetes.
Claims22
A peptide analogue comprising residues 9 to 23 of human insulin B chain of SEQ ID NO:1, wherein the peptide analogue differs in sequence from native human insulin B chain residues 9 to 23 due to amino acid substitutions at between 1 and 4 amino acid positions, wherein at least one substitution occurs at a residue selected from the group consisting of residues 12, 13, 15 and 16, wherein the peptide analogue is capable of reducing incidence of diabetes in non-obese diabetic (NOD) mice, and wherein the peptide analogue consists of no more than 18 residues of human insulin B chain.
A peptide analogue comprising residues 9 to 23 of human insulin B chain of SEQ ID NO:1, wherein the peptide analogue differs in sequence from native human insulin B chain residues 9 to 23 due to amino acid substitutions at residues 16 and 19, wherein the peptide analogue is capable of reducing incidence of diabetes in non-obese diabetic (NOD) mice, and wherein the peptide analogue consists of no more than 18 residues of human insulin B chain.
Dependencies are inferred from the claim text.