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US 6,933,113 B2Granted
Modulation of endogenous gene expression in cells
AssigneeSangamo BioSciences, Inc.
InventorsCasey C. Case, Fyodor Urnov, Albert Lai, Andrew Snowden, Siyuan Tan, Philip Gregory
Life of this patent
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Abstract
Disclosed herein are methods and compositions for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
Claims33
A method of modulating expression of an endogenous cellular gene in a cell, the method comprising the step of:
- contacting the cell with a first polynucleotide encoding a first zinc finger protein, wherein the first zinc finger protein is a fusion protein comprising a designed or selected zinc finger protein in operative linkage with a fimctional domain, further wherein the fusion protein binds to a first target site in the gene;
- thereby modulating expression of the endogenous cellular gene.
Dependencies are inferred from the claim text.