Hapten-carrier conjugates and uses thereof
AssigneeCytos Biotechnology AG
InventorsMartin F. Bachmann, Patrik Maurer
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.
Claims38
A hapten-carrier conjugate comprising:
- (a) a virus-like particle of an RNA phage, comprising at least one first attachment site, and
- (b) at least one drug of abuse hapten with at least one second attachment site;
- wherein said second attachment site is associated through at least one covalent bond to said first attachment site so as to form an ordered and repetitive hapten-carrier conjugate,
- and wherein said drug of abuse is selected from the group consisting of:
- (i) codeine;
- (ii) fentanyl;
- (iii) heroin;
- (iv) morphine;
- (v) amphetamine;
- (vi) cocaine;
- (vii) methylenedioxymethamphetamine;
- (viii) methamphetamine;
- (ix) methylphenidate;
- (x) nicotine;
- (xi) cotinine;
- (xii) nornicotine;
- (xiii) PCP;
- (xiv) LSD;
- (xv) mescaline;
- (xvi) psilocybin;
- (xvii) tetrahydrocannabiflol;
- (xviii) diazepam;
- (xix) desipramine;
- (xx) imipramine;
- (xxi) nortriptyline;
- and
- (xxii) the amitriptyline class of drugs.
Dependencies are inferred from the claim text.