Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
AssigneeBaxter Aktiengesellschaft
InventorsBernhard Laemmle, Helena Elisabeth Gerritsen, Miha Furlan, Peter Turecek, Hans-Peter Schwarz, Friedrich Scheiflinger, Gerhard Antoine, Randolf Kerschbaumer, Luigina Tagliavacca, Klaus Zimmermann
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Abstract
The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.
Claims27
A composition exhibiting vWF protease activity comprising at least one single isolated peptide chain having a molecular weight from about 180 kD to about 120 kD as determined by SDS-PAGE under reducing conditions and comprising the amino acid sequence AAGGILHLELLV (SEQ ID NO:
- 1), wherein the peptide chain is obtained from human plasma.
An isolated polypeptide exhibiting vWF activity, having a molecular weight between 180 kD and 120 kD as determined by SDS-PAGE under reducing conditions and comprising the amino acid sequence AAGGILHLELLV (SEQ ID NO:1), wherein the polypeptide is obtained from human plasma.
An isolated polypeptide having vWF protease activity wherein said polypeptide is obtained from human plasma and comprises the amino acid sequence AAGGILHLELLVAVGDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRV HLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTI (SEQ ID NO:4).
Dependencies are inferred from the claim text.