US 6,924,391 B2Granted

Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors

AssigneeBristol-Myers Squibb Company

InventorsJacques Banville, Roger Remillard, Neelakantan Balasubramanian, Gilles Bouthillier, Alain Martel

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Abstract

Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, X1, R1, R2, Ra, Rb, R3, R4 and Y are as defined in the specification.

Claims2

Dependent claims

A compound selected from

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application: 09/848,694Filed 3 May 2001 · us provisional application
Priority: 11 May 2000
Published: US 2002/0037875 A128 Mar 2002
Granted: 2 Aug 2005
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
A61K 31/197
Having an amino group: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA],…
A61K 31/421
Oxazoles: 1,3-Oxazoles, e.g. pemoline, trimethadione
A61K 31/695
Medicinal preparations containing organic active ingredients: silicon compounds

Family

Application60/203,741Us provisional application · filed 11 May 2000
US 2002/0037875 A1Pre-grant publication · published 28 Mar 2002
US 6,924,391 B2This patent

From the US filing history. Foreign family members aren’t listed.

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