Anti-inflammatory nitro and thia-fatty acids
AssigneesChildren, Youth and Women's Health Service Incorporated, Peptech Limited
InventorsAntonio Ferrante, Christopher J. Easton, Ling Xia
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Abstract
The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is an integer from 0 to 2; or of general formula (I), wherein A′ is a saturated or unsaturated hydrocarbon chain of 9-26 carbon atoms, X is oxygen or is absent and B′ is (CH2)j(COOH)k in which j is an integer from 1 to 3 and k is 0 or 1; and the derivatives thereof in which the hydrocarbon chain includes one or more than one substitution selected from the group consisting of hydroxy, hydroperoxy, epoxy and peroxy. These compounds have biological activity, e.g. as anti-infective or anti-inflammatory agents.
Claims7
An isolated compound having the general formula:
- wherein A is an unsaturated hydrocarbon chain of 14 to 26 carbon atoms or a derivative thereof selected from the group consisiting of hydroxy, hydroperoxy, epoxy and peroxy;
- and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m is 1 or 2;
- wherein the NO2 group is a side group on any of the carbon atoms of A.
Dependencies are inferred from the claim text.