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AssigneeSuomen Punainen Risti, Veripalvelu
InventorsMarc A. R. C. Daemen, Vincent H. Heemskerk, Cornelis van't Veer, Geertrui Denecker, Tim G. A. M. Wolfs, Peter Vandenabeele, Wim A. Buurman, Jaakko Parkkinen
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The present invention comprises a method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia. The method comprises parenterally administering to a patient a therapeutical composition containing natural alpha-1 acid glycoprotein, natural alpha-1 antitrypsin or a mixture thereof. Alternatively, organ or tissue transplants can be contacted with natural alpha-1 acid glycoprotein, natural alpha-antitrypsin or mixtures by perfusing or flushing them with a solution containing natural alpha-1 acid glycoprotein, natural alpha-1 antitrypsin or mixtures thereof in a concentration of 0.1 to 5 g/l.
A method of protecting organs or tissue susceptible to reperfusion-induced dysfunction after ischemia, comprising contacting said organs or tissue with an increased concentration of natural alpha-1 acid glycoprotein, natural alpha-1 antitrypsin or a mixture thereof, relative to the base levels of the natural alpha-1 acid glycoprotein and the natural alpha-1 antitrypsin in the organs or tissue.
A method of protecting organ or tissue transplants against reperfusion injury and dysfunction, comprising contacting said organ or tissue with a preservation fluid for perfusion and storage or rinsing of the organ, or tissue transplants prior to the implantation of said organ or tissue in a patient requiring such implantation, wherein said preservation fluid contains natural alpha-1 acid glycoprotein, natural alpha-1 antitrypsin or a mixture thereof in a concentration sufficient to prevent reperfusion-induced organ dysfunction after ischemia.
A method of protecting organ and tissue transplants against reperfusion injury and dysfunction, comprising administering human alpha-1 acid glycoprotein or human alpha-1 antitrypsin, individually or in combination to the recipient of an organ or tissue transplant.
A method of protecting organs against reperfusion injury and dysfunction comprising administering an effective amount of human alpha-1 acid glycoprotein or human alpha-1 antitrypsin, individually or in combination to a patient undergoing surgical operation.
A method of protecting an organ against reperfusion injury and dysfunction comprising administering an effective amount of human alpha-1 acid glycoprotein or human alpha-1 antitrypsin, individually or in combination to a patient undergoing thrombolytic therapy or revascularisation procedures.
A method of protecting organs against reperfusion injury and dysfunction comprising administering an effective amount of human alpha-1 acid glycoprotein or human alpha-1 antitrypsin, individually or in combination to a patient during treatment of bleeding shock or other forms of shock and hypoperfusion of organs.
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