Methods of modulating hair growth
AssigneeThe General Hospital Corporation
InventorsBruce A. Morgan, Jiro Kishimoto, Robert Burgeson
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Abstract
The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
Claims62
A cell culture, comprising:
- a dermal papilla (DP) cell, a cell culture medium, and a Wnt polypeptide or a functional fragment or analog thereof, in an amount sufficient to promote or maintain the DP cell in anagen phase.
A cell culture, comprising a dermal papilla (DP) cell, a cell culture medium, and a Wnt polypeptide in an amount sufficient to promote or maintain the DP cel in anagen phase.
A cell culture comprising an isolated dermal papilla (DP) cell, cell culture medium, and a recombinant Wnt polypeptide selected from the group consisting of:
- Wnt 3, Wnt 3a, Wnt 4, Wnt 7a and Wnt 7b in amount sufficient to promote or maintain the DP cell in anagen phase.
Dependencies are inferred from the claim text.