Rifamycin biosynthesis gene cluster
AssigneeNovartis AG
InventorsThomas Schupp, Christiane Toupet, Nathalie Engel
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Abstract
The present invention primarily relates to a DNA fragment which is obtainable from the gene cluster responsible for rifamycin biosynthesis within the genome of Amycolatopsis mediterranei, and comprises at least one gene or a part of a gene which codes for a polypeptide which is directly or indirectly involved in the biosynthesis of rifamycin, and to a method for preparing said DNA fragment. The present invention furthermore relates to recombinant DNA molecules which comprise one of the DNA fragments according to the invention, and to the plasmids and vectors derived therefrom. Host organisms transformed with said plasmid or vector DNA are likewise embraced.
Claims7
An isolated DNA fragment wherein said fragment has 90% or greater sequence homology to a region of SEQ ID NO 3 and wherein said fragment encodes one or more of the proteins or polypeptides having a rifamycin biosynthesis enzymatic function possessed by a rifamycin biosynthesis protein selected from the group consisting of the proteins encoded by ORF A, B, C, D, E and F of the Amycolatopsis mediterranei rifamycin synthesis gene cluster.
Dependencies are inferred from the claim text.