Method for preparing a calcium phosphate pasty material for injection

A process for the preparation of an injectable pasty calcium phosphate material comprising mixing water and calcium phosphates to produce a pasty mixture, wherein a methicone in a proportion by weight of greater than 0.30% and less than 10%, based on the mixture, is added to the calcium phosphates or pasty mixture prior to injection, wherein, after injection, the paste mixture containing the methicone develops, hardens, and forms a hydroxyapatite, and

• wherein a methicone with a viscosity of between approximately 20 and 500 centistokes is used.

A process for the preparation of an injectable pasty calcium phosphate material comprising mixing water and calcium phosphates to produce a pasty mixture, wherein a methicone in a proportion by weight of between approximately 0.5% and 1.4%, based on the mixture, is added to the calcium phosphates or pasty mixture prior to injection, wherein, after injection, the paste mixture containing the methicone develops, hardens, and forms a hydroxyapatite.

A process for the preparation of an injectable pasty calcium phosphate material comprising a pasty mixture, wherein the pasty mixture is produced in the cold from a pulverulent cement comprising tricalcium phosphate, tetracalcium phosphate and glycerophosphat powders, and an aqueous solution comprising a calcium compound comprising lime and a phosphate comprising phosphoric acid, mixed at room temperature, wherein a methicone in a proportion by weight of greater than 0.30%. and less than 10%, based on the mixture, is added to the calcium phosphates or pasty mixture prior to injection, wherein, after injection, the paste mixture containing the methicone develops, hardens, and forms a hydroxyapatite, and

• mixing said aqueous solution and said pulverulent cement so that the overall liquid/solid weight ratio is between 0.30and 0.65 to give a homogeneous paste with an overall atomic ratio Ca/P of between 1.50 and 1.67.

A process for the preparation of an injectable pasty calcium phosphate material comprising mixing water and calcium phosphates to produce a pasty mixture, wherein a methicone in a proportion by weight of greater than 0.30% and less than 10%, based on the mixture, is added to the calcium phosphates or pasty mixture prior to injection, wherein, after injection, the paste mixture containing the methzcone develops, hardens, and forms a hydroxyapatite,

• wherein the pasty mixture is produced in the cold from a pulverulent cement comprising tricalcium phosphate and tetracalcium phosphate and an aqueous solution comprising calcium and phosphate, mixed at room temperature, and
• wherein the methicone is solubilized beforehand in a solvent, the resulting liquid phase is mixed with the pulverulent cement and the solvent is allowed to evaporate off.

A surgical or dental kit comprising, in two separate containers, a dose of pulverulent cement of tricalcium phosphate, tetracalcium phosphate and glycerophosphate in a first container, and a dose of aqueous solution of phosphoric acid and lime, in a second container, wherein the dose of pulverulent cement contains a methicone in an amount sufficient to produce an injectable pasty mixture.