Method and apparatus for predicting the risk of hypoglycemia
AssigneeUniversity of Virginia Patent Foundation
InventorsBoris P. Kovatchev, J. Randall Moorman, William L. Clarke, Martin Straume
Life of this patent
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Abstract
The invention relates to a method which utilizes blood glucose (“BG”) sampling, insulin infusion/injection records, heart rate (“HR”) information and heart rate varability (“HRV”) information to estimate BG in the near future and to estimate of the risk of the onset of hypoglycemia. The invention also relates to an apparatus for predicting BG levels and for assessing the risk of the onset of hypoglycemia in the near future. The invention is based on two predetermined bio-mathematical routines: a network model of BG fluctuations and a BG profile for assessment of the risk of hypoglycemia.
Claims16
A method for predicting a near future BG profile and the onset of hypoglycemia comprising the steps of:
- monitoring and recording a BG history profile;
- monitoring and recording an insulin infusion and/or injection history profile;
- monitoring and recording a HR history profile as an estimate of physical activity;
- monitoring and recording a HRV history profile as an estimate of sympathetic nervous system activity;
- determining a predicted near future BG profile using a first predetermined bio-mathematical routine;
- and
- evaluating the near future BG profile to predict the onset of hypoglycemia in the near future based on an assessed risk of hypoglycemia, wherein the assessed risk of hypoglycemia is determined using a second predetermined bio-mathematical routine using a computerized processor.
A method for predicting a near future BG profile and the onset of hypoglycemia in the near future comprising the steps of:
- receiving data input regarding BG history, insulin infusion/injection history, HR history, and HRV history;
- evaluating the data input received using a first predetermined bio-mathematical routine to predict a near future BG profile;
- and
- evaluating the near future BG profile to predict the onset of hypoglycemia in the near future based on an assessed risk of hypoglycemia, wherein the assessed risk of hypoglycemia is determined using a second predetermined bio-mathematical routine using a computerized processor.
An apparatus for predicting a near future BG profile and the onset of hypoglycemia comprising:
- a BG history profile recording mechanism;
- an insulin infusion and/or injection history profile recording mechanism;
- a HR history profile recording mechanism;
- a HRV history profile recording mechanism;
- a near future BG profile prediction module for predicting the near future BG profile using a first predetermined bio-mathematical routine;
- and
- a hypoglycemia prediction module for predicting the onset of hypoglycemia based on an assessed risk of hypoglycemia, wherein the assessed risk of hypoglycemia is determined by a computer processor using a second predetermined bio-mathematical routine.
An apparatus for predicting a near future BG profile and the onset of hypoglycemia comprising:
- an interface for receiving data regarding BG history, insulin infusion and/or injection history, HR history, and HRV history profiles;
- a BG prediction module for predicting a near future BG profile using a first predetermined bio-mathematical routine;
- and
- a hypoglycemia prediction module for predicting the onset of hypoglycemia in the near future based on an assessed risk of hypoglycemia, wherein the assessed risk of hypoglycemia is determined by a computer processor using a second predetermined bio-mathematical routine.
Dependencies are inferred from the claim text.