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US 6,919,339 B2Granted
ABCA-1 elevating compounds
AssigneeCV Theapeutics, Inc.
InventorsMichael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
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Abstract
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
Claims20
A compound of the Formula I
- wherein:
- A is a covalent bond;
- R1 and R2 are hydrogen;
- R3 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
- and
- R4 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
- with the proviso that
- when R4 is methyl or ethyl, R3 cannot be lower alkyl or unsubstituted phenyl.
5 more elements
A method of treating atherosclerosis in a mammal comprising administering to a mammal in need thereof a therapeutically effective dose of a compound of Formula I:
- wherein:
- A is a covalent bond;
- R1 and R2 are hydrogen;
- R3 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl;
- and
- R4 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl.
3 more elements
Dependencies are inferred from the claim text.