Method for identifying autoimmune disease, method for detecting anti-Reg protein autoantibody and diagnostics for autoimmune disease
AssigneeHiroshi Okamoto
InventorHiroshi Okamoto
Life of this patent
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Abstract
A method for judging an autoimmune disease by detecting the existence of an anti-Reg protein autoantibody in a specimen; and a method for judging insulin-dependent or non-insulin-dependent diabetes mellitus. A method for detecting an anti-Reg protein autoantibody by bringing into a specimen into contact with an antigen component and detecting the formation of an immune complex. A reagent for diagnosing autoimmune disease which contain an antigen component capable of binding specifically to the anti-Reg protein autoantibody; and a reagent for diagnosing insulin-dependent or non-insulin-dependent diabetes mellitus.
Claims11
A method for identifying a human autoimmune disease in a human patient suspected of having autoimmune disease, which comprises:
- providing a specimen from the patient;
- detecting a human anti-Reg protein autoantibody in the specimen;
- and
- identifying a human autoimmune disease in the patient by comparing a level of the human anti-Reg protein autoantibody in the specimen to an average level of human anti-Reg protein autoantibody in a healthy population which does not have a human autoimmune disease.
A method for identifying diabetes mellitus in a human patient suspected of having diabetes mellitus, which comprises:
- providing a specimen from the patient;
- detecting a human anti-Reg protein autoantibody in the specimen;
- and
- identifying diabetes mellitus in the patient by comparing a level of the human anti-Reg protein autoantibody in the specimen to an average level of human anti-Reg protein autoantibody in a healthy population which does not have diabetes mellitus.
A method for detecting a human anti-Reg protein autoantibody which comprises:
- providing a specimen;
- bringing the specimen into contact with a human Reg protein capable of binding specifically to the human anti-Reg protein autoantibody in the specimen;
- and
- detecting an immune complex resulting from a reaction of the human anti-Reg protein autoantibody in the specimen with the human Reg protein capable of binding specifically to the human anti-Reg protein autoantibody in the specimen.
A reagent comprising latex particles, wherein a human Reg protein capable of binding specifically to a human anti-Reg protein autoantibody is directly immobilized to the latex particle.
A reagent which comprises a human Reg protein capable of binding specifically to a human anti-Reg protein autoantibody and a labeled second antibody which reacts with the human anti-Reg protein autoantibody.
Dependencies are inferred from the claim text.