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US 6,916,940 B2Granted
Method for producing cyclic carboxylic orthoester fluorides and corresponding compounds
AssigneeMerck Patent GmbH
InventorsPeer Kirsch, Andreas Taugerbeck
Life of this patent
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Abstract
The invention relates to a process for the preparation of cyclic carboxylic acid orthoester fluorides in which a) at least one bis(alkylthio)carbenium salt is reacted with at least one organic compound containing at least two hydroxyl groups in the presence of at least one base, b) and subsequently, preferably in situ, the resultant thioorthoester is subjected to oxidative fluorodesulfurisation using a fluorinating agent and an oxidant to give the cyclic carboxylic acid orthoester fluoride.
Claims15
A process for preparing a cyclic carboxylic acid orthoester fluoride, comprising reacting:
- a) at least one bis(alkylthio)carbenium salt with at least one organic compound containing at least two hydroxyl groups in the presence of at least one base,
- b) and subsequently, subjecting to oxidative fluoride sulfurisation using a fluorinating agent and an oxidant the resultant thioorthoester to give the cyclic carboxylic acid orthoester fluoride.
Dependencies are inferred from the claim text.