Secreted and transmembrane polypeptides and nucleic acids encoding the same
AssigneeGenentech, Inc.
InventorsAudrey Goddard, Paul J. Godowski, Austin L. Gurney, Margaret Ann Roy, William I. Wood
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Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims14
An isolated nucleic acid comprising:
- (a) the nucleic acid sequence of SEQ ID NO:131;
- (b) the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:131, with or without nucleotides encoding the signal sequence of the polypeptide of SEQ ID NO:132;
- or
- (c) the full-length coding sequence of the cDNA deposited under ATCC accession number 209784.
An isolated nucleic acid consisting of an at least 50 nucleotides fragment of the nucleic acid sequence of SEQ ID NO:
- 131, or a complement thereof, that specifically hybridizes under stringent conditions to:
- the nucleic acid sequence of SEQ ID NO:
- 131, or a complement thereof,
- wherein said stringent conditions use 50% formamide, 5×SSC, 50 mM sodium phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5× Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1% SDS, and 10% dextran sulfate at 42° C., with washes at 42° C. in 0.2×SSC and 50% formamide at 55° C., followed by a wash comprising of 0.1×SSC containing EDTA at 55° C.
Dependencies are inferred from the claim text.