Human antibodies that bind human IL-12 and methods for producing

An isolated human antibody, or an antigen-binding portion thereof, which:

• a) inhibits phytohemagglutinin blast proliferation in an in vitro PHA assay with an IC50 of 1×10−9M or less;
• b) has a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 25;
• and
• c) has a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 26.

An isolated human antibody, or an antigen-binding portion thereof, which:

• a) disassociates from human IL-12 with a koff rate constant of 1×10−3S−1or less, as determined by surface plasmon resonance;
• b) has a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 25;
• and
• c) has a light chain CDR3 comprising the amino acid sequence of SEQ ID NO:
• 26.

An isolated human antibody, or antigen-binding portion thereof, that binds to human IL-12 and comprises:

• a light chain CDR3 domain comprising the amino acid sequence of SEQ ID NO:
• 26;
• and
• a heavy chain CDR3 domain comprising the amino acid sequence of SEQ ID NO:
• 25.

A pharmaceutical composition comprising an antibody or an antigen binding portion thereof, and a pharmaceutically acceptable carrier, wherein the antibody comprises:

• a light chain CDR3 domain comprising the amino acid sequence of SEQ ID NO:
• 26;
• and
• a heavy chain CDR3 domain comprising the amino acid sequence of SEQ ID NO:
• 25.