Nanostructured separation and analysis devices for biological membranes
AssigneeScience & Technology Corporation @ UNM
InventorsGabriel P. Lopez, Steven R. Brueck, Linnea K. Ista
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Abstract
The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
Claims37
A nanostructured device comprising:
- a substrate including at least one nanotrough therein;
- and
- a lipid bilayer suspended over said at least one nanotrough.
A nanostructured device comprising:
- a substrate including at least one nanotrough therein;
- and
- at least one lipid bilayer supported in at least one of said at least one nanotroughs so as to allow biomolecules to pass from said at least one lipid bilayer into said at least one respective nanotrough.
A separation method comprising the steps of:
- (a) supporting or suspending a lipid bilayer on a substrate;
- wherein said substrate comprises at least one nanostructure and wherein said lipid bilayer comprises at least one membrane associated biomolecule;
- and
- (b) applying a driving force to said lipid bilayer to separate said at least one membrane associate biomolecule from said lipid bilayer and to drive said at least one membrane associated biomolecule within said lipid bilayer into said at least one nanostructure.
Dependencies are inferred from the claim text.